What is a normal albumin globulin ratio?

The normal A/G ratio is generally between 1.0 and 2.5, with most laboratories citing a typical reference range of 1.1 to 2.1. A ratio above 1.0 means there is more albumin than globulin in the blood, which is normal. A ratio below 1.0 (reversed A/G ratio) can indicate elevated globulin production, reduced albumin synthesis, or both. A very high ratio above 2.5 may suggest low globulin levels. Always interpret your result alongside your laboratory's own reference range and in the context of your symptoms and other test results.

How is the A/G ratio calculated?

The A/G ratio is calculated by dividing serum albumin by serum globulin. Globulin is not usually measured directly; it is derived by subtracting albumin from total protein (Globulin = Total Protein - Albumin). The formula is therefore: A/G Ratio = Albumin / (Total Protein - Albumin). For example, if albumin is 42 g/L and total protein is 72 g/L, then globulin is 30 g/L and the A/G ratio is 42 / 30 = 1.40.

Albumin Globulin Ratio Calculator

Calculate your serum albumin to globulin (A/G) ratio from a blood test result. Enter your albumin and total protein values and the calculator derives globulin and computes the ratio instantly.

The A/G ratio is a simple index used alongside liver function tests and serum protein electrophoresis to help identify liver disease, kidney disease, inflammatory conditions, and immune disorders.

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Reviewed June 2026 Formula: A/G Ratio = Albumin / (Total Protein − Albumin). Standard clinical biochemistry method.

For educational purposes only. This calculator is not a diagnostic tool. Always discuss blood test results with your doctor or a registered health professional. Reference ranges vary between laboratories.

1. Your Blood Test Values

Units (select before entering values)

Serum albumin (normal: 35–50 g/L)

g/L

Total protein (normal: 60–80 g/L)

g/L

2. Derived Values

Globulin (calculated)

g/L

Typical normal ranges

Albumin	35–50 g/L
Total protein	60–80 g/L
Globulin	20–35 g/L
A/G Ratio	1.0–2.5

A/G Ratio Result

Albumin

g/L

Globulin

g/L

Total Protein

g/L

A/G Ratio
--
Albumin / Globulin

Calculation Breakdown

Serum albumin--

Total protein--

Globulin = Total Protein − Albumin--

A/G Ratio = Albumin ÷ Globulin--

Interpretation Guide

Below 1.0Low (reversed ratio)

1.0 to 1.1Borderline low

1.1 to 2.5Normal range

Above 2.5High (check globulin)

Your result--

Status--

Result: Enter your albumin and total protein values above to calculate your A/G ratio.

What Is the Albumin Globulin Ratio?

The albumin globulin (A/G) ratio is the proportion of albumin to globulin in the blood. Both are classes of serum proteins measured as part of a total protein test or a comprehensive metabolic panel. Albumin is made by the liver and performs functions such as maintaining fluid pressure and transporting hormones and drugs. Globulins are a broader group including immune proteins (immunoglobulins) and enzymes.

A healthy adult has more albumin than globulin in the blood, giving an A/G ratio above 1.0. When the ratio falls below 1.0 or rises well above 2.5, it can indicate an underlying condition that warrants further investigation.

The Formula

Globulin is not usually reported directly by laboratories. It is calculated from two reported values:

Globulin = Total Protein − Albumin
A/G Ratio = Albumin ÷ Globulin

For example: if albumin is 42 g/L and total protein is 72 g/L, then globulin is 30 g/L and the A/G ratio is 42 ÷ 30 = 1.40.

Normal Range

Measure	Typical Normal Range (g/L)	Typical Normal Range (g/dL)
Serum albumin	35–50 g/L	3.5–5.0 g/dL
Total protein	60–80 g/L	6.0–8.0 g/dL
Globulin (derived)	20–35 g/L	2.0–3.5 g/dL
A/G Ratio	1.0–2.5 (no units)

Reference ranges vary slightly between laboratories. Always compare your result against your own lab's stated reference interval.

What Does a Low A/G Ratio Mean?

A low A/G ratio (below 1.0) is called a reversed A/G ratio. It usually means albumin is lower than expected, globulin is higher than expected, or both. Common causes include:

Liver disease: cirrhosis, hepatitis, or liver failure can reduce albumin production.
Kidney (nephrotic) syndrome: albumin is lost through damaged kidney filters.
Malnutrition or malabsorption: inadequate protein intake reduces albumin levels.
Chronic inflammation or autoimmune diseases: inflammatory cytokines suppress albumin and raise globulins.
Multiple myeloma or other blood cancers: abnormal plasma cells produce excess immunoglobulins, raising globulin and lowering the ratio.

What Does a High A/G Ratio Mean?

A high A/G ratio (above 2.5) usually reflects low globulin, which is less common but can occur in:

Immunodeficiency disorders where immunoglobulin production is low.
Certain genetic conditions affecting globulin synthesis.
Steroid or corticosteroid use, which can suppress immunoglobulin levels.

A mildly elevated ratio is often not clinically significant on its own.

Worked Example

A routine blood panel reports: albumin 42 g/L, total protein 72 g/L.

Globulin = 72 − 42 = 30 g/L
A/G Ratio = 42 ÷ 30 = 1.40
Interpretation: within the normal range (1.0–2.5).

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Sources and method: Pagana KD, Pagana TJ. Mosby's Manual of Diagnostic and Laboratory Tests (6th ed.). Formula: A/G Ratio = Albumin / (Total Protein − Albumin). Reference ranges based on standard clinical biochemistry practice; individual laboratory ranges may differ.

This calculator is for educational purposes only and is not a substitute for professional medical advice. Reference ranges vary between laboratories and testing methods. Always discuss your blood test results with your doctor or a qualified health professional.